- Samuel L. Jackson (33 movies)
- Seth Rogen (25 movies)
- Steve Buscemi (23 movies)
- Stan Lee (21 movies)
- Stanley Tucci (19 movies)
- Steve Carell (19 movies)
- Simon Pegg (18 movies)
- Sigourney Weaver (16 movies)
- Stephen Root (16 movies)
- Susan Sarandon (16 movies)
- Scarlett Johansson (15 movies)
- Sean Bean (14 movies)
- Shia LaBeouf (14 movies)
- Sam Elliott (13 movies)
- Sam Rockwell (13 movies)
- Shea Whigham (13 movies)
- Sam Shepard (12 movies)
- Seann William Scott (12 movies)
- Scott Adkins (11 movies)
- Stellan Skarsgård (11 movies)
- Sadie Sandler (10 movies)
- Sandra Bullock (10 movies)
- Steve Coogan (10 movies)
- Sylvester Stallone (10 movies)
- Sacha Baron Cohen (9 movies)
- Salma Hayek (9 movies)
- Scoot McNairy (9 movies)
- Sean Penn (9 movies)
- Sienna Miller (9 movies)
- Simon McBurney (9 movies)
- Sam Worthington (8 movies)
- Sebastian Stan (8 movies)
- Shirley Henderson (8 movies)
- Sienna Guillory (8 movies)
- Stephen Dorff (8 movies)
- Stephen McHattie (8 movies)
- Steve Zahn (8 movies)
- Sung Kang (8 movies)
- Sam Neill (7 movies)
- Sam Spruell (7 movies)
- Saoirse Ronan (7 movies)
- Sarah Gadon (7 movies)
- Sarah Jessica Parker (7 movies)
- Seth MacFarlane (7 movies)
- Sharlto Copley (7 movies)
- Sherry Lynn (7 movies)
- Stephen Fry (7 movies)
- Stephen Graham (7 movies)
- Stephen Kearin (7 movies)
- Stephen Tobolowsky (7 movies)