- Sandra Oh (6 movies)
- Sarah Silverman (6 movies)
- Scott Glenn (6 movies)
- Sean Connery (6 movies)
- Sean Hayes (6 movies)
- Selma Blair (6 movies)
- Shailene Woodley (6 movies)
- Sharon Conley (6 movies)
- Shaun Toub (6 movies)
- Shiloh Fernandez (6 movies)
- Shirley MacLaine (6 movies)
- Shohreh Aghdashloo (6 movies)
- Silas Carson (6 movies)
- Sofía Vergara (6 movies)
- Stacy Keach (6 movies)
- Steven Berkoff (6 movies)
- Saïd Taghmaoui (5 movies)
- Sally Hawkins (5 movies)
- Sam Claflin (5 movies)
- Sandrine Holt (5 movies)
- Sarah Michelle Gellar (5 movies)
- Sarah Shahi (5 movies)
- Sarita Choudhury (5 movies)
- Scott Lawrence (5 movies)
- Scott Speedman (5 movies)
- Sean Astin (5 movies)
- Sean Harris (5 movies)
- Sean O'Bryan (5 movies)
- Selena Gomez (5 movies)
- Shaquille O'Neal (5 movies)
- Shawn Roberts (5 movies)
- Shawnee Smith (5 movies)
- Siobhan Fallon (5 movies)
- Snoop Dogg (5 movies)
- Sofia Coppola (5 movies)
- Stephen Campbell Moore (5 movies)
- Stephen Lang (5 movies)
- Stephen Merchant (5 movies)
- Steve Martin (5 movies)
- Sally Field (4 movies)
- Sally Phillips (4 movies)
- Sam Jaeger (4 movies)
- Sam Riley (4 movies)
- Samantha Bond (4 movies)
- Sami Gayle (4 movies)
- Sanaa Lathan (4 movies)
- Sandra Ellis Lafferty (4 movies)
- Sarah Paulson (4 movies)
- Sasha Barrese (4 movies)
- Saul Rubinek (4 movies)