- Sally Hawkins (5 movies)
- Sam Claflin (5 movies)
- Sandrine Holt (5 movies)
- Sarah Michelle Gellar (5 movies)
- Sarah Shahi (5 movies)
- Sarita Choudhury (5 movies)
- Scott Lawrence (5 movies)
- Scott Speedman (5 movies)
- Sean Astin (5 movies)
- Sean Harris (5 movies)
- Sean O'Bryan (5 movies)
- Selena Gomez (5 movies)
- Shaquille O'Neal (5 movies)
- Shawn Roberts (5 movies)
- Shawnee Smith (5 movies)
- Siobhan Fallon (5 movies)
- Snoop Dogg (5 movies)
- Sofia Coppola (5 movies)
- Stephen Campbell Moore (5 movies)
- Stephen Lang (5 movies)
- Stephen Merchant (5 movies)
- Steve Martin (5 movies)
- Sandra Oh (6 movies)
- Sarah Silverman (6 movies)
- Scott Glenn (6 movies)
- Sean Connery (6 movies)
- Sean Hayes (6 movies)
- Selma Blair (6 movies)
- Shailene Woodley (6 movies)
- Sharon Conley (6 movies)
- Shaun Toub (6 movies)
- Shiloh Fernandez (6 movies)
- Shirley MacLaine (6 movies)
- Shohreh Aghdashloo (6 movies)
- Silas Carson (6 movies)
- Sofía Vergara (6 movies)
- Stacy Keach (6 movies)
- Steven Berkoff (6 movies)
- Sam Neill (7 movies)
- Sam Spruell (7 movies)
- Saoirse Ronan (7 movies)
- Sarah Gadon (7 movies)
- Sarah Jessica Parker (7 movies)
- Seth MacFarlane (7 movies)
- Sharlto Copley (7 movies)
- Sherry Lynn (7 movies)
- Stephen Fry (7 movies)
- Stephen Graham (7 movies)
- Stephen Kearin (7 movies)
- Stephen Tobolowsky (7 movies)